GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.

Hughan, S. C., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, McCarty, O. J. T., Schweighoffer, E., Soultanova, I., Ware, J., Tybulewicz, V. L. J. and Watson, S. P. (2007) GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arteriosclerosis, Thrombosis, and Vascular Biology, 27 (2). pp. 422-9. ISSN 1079-5642

Abstract/Summary

We show that Syk is critical for lamellipodia formation on a range of immobilized proteins but that this can be overcome by addition of thrombin. Further, we reveal a novel role for GPVI in supporting thrombin-induced activation, independent of Syk and Src kinases.