Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex.

Riba, R., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Graham, A., Watson, S. P. and Naseem, K. M. (2008) Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex. Journal of thrombosis and haemostasis : JTH, 6 (6). pp. 1012-20. ISSN 1538-7836

Abstract/Summary

We identify gAd as a novel ligand for GPVI that stimulates tyrosine kinase-dependent platelet aggregation. Our data raise the possibility that gAd may promote unwanted platelet activation at sites of vascular injury.