Evidence for a genetic interaction in allergy-related responsiveness to vitamin D deficiency

Vimaleswaran, K. S. ORCID: https://orcid.org/0000-0002-8485-8930, Cavadino, A. and Hyppönen, E. (2012) Evidence for a genetic interaction in allergy-related responsiveness to vitamin D deficiency. Allergy, 67 (8). pp. 1033-1040. ISSN 1398-9995 doi: 10.1111/j.1398-9995.2012.02856.x

Abstract/Summary

Our study on white European adults was consistent with a previous study on children from largely non-white ethnic groups, suggesting that IL4 and MS4A2 genotypes modify the association between VDD and allergy risk. The risk allele in IL4 is present in nearly 90% of white Europeans, while less than a quarter are carriers in some other populations, highlighting the need to consider possible ethnic differences in allergy-related responsiveness to VDD.