Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current

Dallas, M. L. ORCID: https://orcid.org/0000-0002-5190-0522, Yang, Z., Boyle, J. P., Boycott, H. E., Scragg, J. L., Milligan, C. J., Elies, J., Duke, A., Thireau, J., Reboul, C., Richard, S., Bernus, O., Steele, D. S. and Peers, C. (2012) Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current. American Journal of Respiratory and Critical Care Medicine, 186 (7). pp. 648-656. ISSN 1073-449X doi: 10.1164/rccm.201204-0688OC

Abstract/Summary

Our data indicate that the proarrhythmic effects of CO arise from activation of NO synthase, leading to NO-mediated nitrosylation of Na(V)1.5 and to induction of the late Na(+) current. We also show that the antianginal drug ranolazine can abolish CO-induced early after-depolarizations, highlighting a novel approach to the treatment of CO-induced arrhythmias.