Natural product pharmacology: the British Journal of Pharmacology perspective

Wang, X., Izzo, A. A., Papapetropoulos, A., Alexander, S. P. H., Cortese-Krott, M., Kendall, D. A., Martemyanov, K. A., Mauro, C., Panettieri Jr, R. A., Patel, H. H., Schulz, R., Stefanska, B., Stephens, G. J. ORCID: https://orcid.org/0000-0002-8966-4238, Teixeira, M. M., Vergnolle, N. and Ferdinandy, P. (2024) Natural product pharmacology: the British Journal of Pharmacology perspective. British Journal of Pharmacology, 181 (19). pp. 3547-3555. ISSN 0007-1188 doi: 10.1111/bph.17300

Abstract/Summary

Natural products (NPs) have long been used as a rich source of bioactive compounds for drug development, and recent technological advancements have revitalised NP research as evidenced by increased publications in this field. In this editorial review, we highlight key points from the 2020 BJP practical guide, which outlines standards for NP research reports, and provide papers published in BJP between years 2020 to 2023 that demonstrate adherence to these guidelines. Looking ahead, we discuss the potential of chemical proteomics approaches to elucidate NP mechanisms of action and identify therapeutic targets for future research. By fostering innovation, we aim to advance NP research and contribute to the development of novel therapeutics that will have a significant impact on healthcare.