Items where Division is "Medicinal Chemistry Research Group"

2023

Pozza, M. D., Mesdom, P., Abdullrahman, A., Prieto Otoya, T. D., Arnoux, P., Frochot, C. ORCID: https://orcid.org/0000-0002-7659-3864, Niogret, G., Saubaméa, B., Burckel, P., Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Hollenstein, M. ORCID: https://orcid.org/0000-0003-0263-9206, Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 and Gasser, G. ORCID: https://orcid.org/0000-0002-4244-5097 (2023) Increasing the π-expansive ligands in ruthenium(II) polypyridyl complexes: synthesis, characterization, and biological evaluation for photodynamic therapy applications. Inorganic Chemistry, 62 (45). pp. 18510-18523. ISSN 1520-510X doi: 10.1021/acs.inorgchem.3c02606

2022

Khater, M., Watson, K. A. ORCID: https://orcid.org/0000-0002-9987-8539, Boateng, S. Y., Greco, F. and Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457 (2022) Halogenated flavonoid derivatives display antiangiogenic activity. Molecules, 27 (15). 4757. ISSN 1420-3049 doi: 10.3390/molecules27154757

McQuaid, K. T. ORCID: https://orcid.org/0000-0002-3222-5584, Takahashi, S., Baumgaertner, L., Cardin, D. J., Paterson, N. G., Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Sugimoto, N. and Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 (2022) Ruthenium polypyridyl complex bound to a unimolecular chair-form G-quadruplex. Journal of the American Chemical Society, 144 (13). pp. 5956-5964. ISSN 0002-7863 doi: 10.1021/jacs.2c00178

2021

Dawood, D. H., Srour, A. M., Saleh, D. O., Huff, K. J., Greco, F. and Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457 (2021) New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents. RSC Advances, 11. pp. 29441-29452. ISSN 2046-2069 doi: 10.1039/D1RA04758B

Manzoni, C. and Ferrari, R. (2021) Mendelian and sporadic FTD: disease risk and avenues from genetics to disease pathways through in silico modelling. In: Ghetti, B., Buratti, E., Boeve, B. and Rademakers, R. (eds.) Frontotemporal Dementias. Advances in Experimental Medicine and Biology, 1281. Springer, pp. 283-296. ISBN 9783030511395 doi: 10.1007/978-3-030-51140-1_17

2020

Baptista, F. R., Devereux, S. J., Gurung, S. P., Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Sazanovich, I. V., Towrie, M., Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995, Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Kelly, J. M. and Quinn, S. J. (2020) The influence of loops on the binding of the [Ru(phen)2dppz]2+ light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy. Chemical Communications, 56 (67). pp. 9703-9706. ISSN 1359-7345 doi: 10.1039/D0CC03702H

2019

Strohfeldt, K. (2019) The power of the virtual client – using problem-based learning as a tool for integration in a pharmaceutical sciences laboratory course. Higher Education Pedagogies, 4 (1). pp. 462-475. ISSN 2375-2696 doi: 10.1080/23752696.2019.1686647

2018

Bootman, M. D., Allman, S., Rietdorf, K. and Bultynck, G. (2018) Deleterious effects of calcium indicators within cells: an inconvenient truth. Cell Calcium, 73. pp. 82-87. ISSN 0143-4160 doi: 10.1016/j.ceca.2018.04.005

2016

Bryant, L. A., Fanelli, R. and Cobb, A. J. A. (2016) Cupreines and cupreidines: an established class of bifunctional cinchona organocatalysts. Beilstein Journal of Organic Chemistry, 12. pp. 429-443. ISSN 1860-5397 doi: 10.3762/bjoc.12.46

Sinclair, F., Chen, L., Greenland, B. W. and Shaver, M. P. (2016) Installing multiple functional groups on biodegradable polyesters via post-polymerization olefin cross-metathesis. Macromolecules, 49 (18). pp. 6826-6834. ISSN 0024-9297 doi: 10.1021/acs.macromol.6b01571

2015

Greenland, B. W. and Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 (2015) Donor-acceptor π−π stacking interactions: from small molecule complexes to healable supramolecular polymer networks. In: Supramolecular polymer networks and gels. Advances in Polymer Science. Springer, pp. 143-166.

Kikuta, K., Piao, H., Brazier, J. ORCID: https://orcid.org/0000-0002-4952-584X, Taniguchi, Y., Onizuka, K., Nagatsugi, F. and Sasaki, S. (2015) Stabilization of the i-motif structure by the intra-strand cross-link formation. Bioorganic & Medicinal Chemistry Letters, 25 (16). pp. 3307-3310. ISSN 0960-894X doi: 10.1016/j.bmcl.2015.05.064

Strohfeldt, K. and Khutoryanskaya, O. (2015) Using problem-based learning in a chemistry practical class for pharmacy students and engaging them with feedback. American Journal of Pharmaceutical Education, 79 (9). 141. ISSN 1553-6467 doi: 10.5688/ajpe799141

2014

Harvey, D. J., Edgeworth, M., Krishna, B. A., Bonomelli, C., Allman, S. A., Crispin, M. and Scrivens, J. H. (2014) Fragmentation of negative ions from N-linked carbohydrates: Part 6. Glycans containing oneN-acetylglucosamine in the core. Rapid Communications in Mass Spectrometry, 28 (18). pp. 2008-2018. ISSN 0951-4198 doi: 10.1002/rcm.6980

Rajora, A. K., Ravishankar, D., Osborn, H. M.I. ORCID: https://orcid.org/0000-0002-0683-0457 and Greco, F. (2014) Impact of the enhanced permeability and retention (EPR) effect and cathepsins levels on the activity of polymer-drug conjugates. Polymers, 6 (8). pp. 2186-2220. ISSN 2073-4360 doi: 10.3390/polym6082186

Steinke, J. H. G., Greenland, B. W., Johns, S., Parker, M. P., Atkinson, R. C. J., Cade, I. A. and Trussell, S. J. (2014) Robust and operationally simple synthesis of Poly(bis(2,2,2- trifluoroethoxy) phosphazene) with controlled molecular weight, low PDI, and high conversion. ACS Macro Letters, 3. pp. 548-551. ISSN 2161-1653 doi: 10.1021/mz500199x

Vaiyapuri, R., Greenland, B., Colquhoun, H. M., Elliott, J. M. ORCID: https://orcid.org/0000-0001-7469-4154 and Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 (2014) Evolution of supramolecular healable composites: a minireview. Polymer International, 63 (6). pp. 933-942. ISSN 0959-8103 doi: 10.1002/pi.4685

2013

Alonzi, D. S., Kukushkin, N. V., Allman, S. A., Hakki, Z., Williams, S. J., Pierce, L., Dwek, R. A. and Butters, T. D. (2013) Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins. Cellular and Molecular Life Sciences, 70 (15). pp. 2799-2814. ISSN 1420-682X doi: 10.1007/s00018-013-1304-6

Bajaj, N., Hart, L. R., Greenland, B. W. and Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 (2013) Urea organogelators: synthesis and properties. Macromolecular Symposia, 329 (1). pp. 118-124. ISSN 1022-1360 doi: 10.1002/masy.201200103

Cheng, G., Greenland, B. W., Lampard, C., Williams, N., Bahra, M. S. and Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 (2013) Lightly branched comb polyesters: application in fast drying solvent-borne coating formulations. Reactive & Functional Polymers, 73 (4). pp. 619-623. ISSN 1381-5148 doi: 10.1016/j.reactfunctpolym.2013.01.008

Cheng, G., Greenland, B. W., Lampard, C., Williams, N., Barhra, M. S. and Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 (2013) Synthesis of novel hyperbranched polymers featuring oxazoline linear units and their application in fast-drying solvent-borne coating formulations. Journal of Polymer Science Part A: Polymer Chemistry, 51 (18). pp. 3964-3974. ISSN 1099-0518 doi: 10.1002/pola.26807

Cobb, A., Arezki, N., Dell'Isola, A. and Aitken, L. (2013) Asymmetric organocatalysis and the nitro group functionality. Synthesis-Stuttgart, 45 (19). pp. 2627-2648. ISSN 0039-7881 doi: 10.1055/s-0033-1338522

Greenland, B. W. and Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 (2013) Healable polymeric materials. In: Greenland, B. W. and Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 (eds.) Healable polymer systems. Royal Society of Chemistry, London, pp. 1-15. ISBN 9781849736268 doi: 10.1039/9781849737470-00001

Greenland, B. W., Bird, M. B., Burattini, S., Cramer, R. ORCID: https://orcid.org/0000-0002-8037-2511, O'Reilly, R. K., Patterson, J. P., Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991, Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 and Colquhoun, H. M. (2013) Mutual binding of polymer end-groups by complementary π–π-stacking: a molecular “Roman Handshake”. Chemical Communications, 49 (5). pp. 454-456. ISSN 1359-7345 doi: 10.1039/C2CC35965K

Greenland, B. W., Fiore, G. L., Rowan, S. J. and Weder, C. (2013) Healable supramolecular polymeric materials. In: Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 and Greenland, B. W. (eds.) Healable Polymer Systems. Royal Society of Chemistry, Cambridge, pp. 92-125. ISBN 9781849736268 doi: 10.1039/9781849737470-00092

Hart, L. R., Harries, J. L., Greenland, B. W., Colquhoun, H. M. and Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 (2013) Healable supramolecular polymers. Polymer Chemistry, 4. pp. 4860-4870. ISSN 1759-9954 doi: 10.1039/C3PY00081H

Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 and Greenland, B. W., eds. (2013) Healable Polymer Systems. Royal Society of Chemistry, Cambridge, pp165. ISBN 9781849736268

Rajkumar, S., Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155, Goodman, J. M. and Cobb, A. J.A. (2013) Organocatalytic domino reaction of cyanosulfones: access to complex cyclohexane systems with quaternary carbon centers. Organic Letters, 15 (6). pp. 1386-1389. ISSN 1523-7060 doi: 10.1021/ol400356k

Ravishankar, D., Rajora, A., Greco, F. and Osborn, H. ORCID: https://orcid.org/0000-0002-0683-0457 (2013) Flavonoids as prospective compounds for anti-cancer therapy. International Journal of Biochemistry and Cell Biology, 45 (12). pp. 2821-2831. ISSN 1878-5875 doi: 10.1016/j.biocel.2013.10.004

2012

Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Shah, A. and Brown, G. D. (2012) I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes. Chemical Communication, 48 (87). pp. 10739-10741. ISSN 1359-7345 doi: 10.1039/C2CC30863K

Rajkumar, S., Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155, Brown, G. D. and Cobb, A. (2012) Organocatalytic enantioselective construction of nitrocyclohexanes containing multiple chiral centres via a cascade reaction. Chemical Science, 3. pp. 584-588. ISSN 1478-6524 doi: 10.1039/C1SC00592H

Rangam, G., Schmitz, K.-M., Cobb, A. and Petersen-Mahrt, S. (2012) AID enzymatic activity is inversely proportional to the size of cytosine C5 orbital cloud. PloS ONE, 7 (8). e43279. ISSN 1932-6203 doi: 10.1371/journal.pone.0043279

Shaikh, A. K., Cobb, A. J. A. and Varvounis, G. (2012) Mild and rapid method for the generation of ortho-(naphtho)-quinone methide intermediates. Organic Letters, 14 (2). pp. 584-587. ISSN 1523-7060 doi: 10.1021/ol203196n

2011

Benning, R. K., Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457 and Turkson, A. (2011) Regioselective Beckmann rearrangements of furanoside and pyranoside-derived oximes. Tetrahedron: Asymmetry, 22 (1). pp. 109-116. ISSN 0957-4166 doi: 10.1016/j.tetasy.2010.11.031

Burland, P. A., Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457 and Turkson, A. (2011) Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes. Bioorganic & Medicinal Chemistry, 19 (18). pp. 5679-5692. ISSN 0968-0896 doi: 10.1016/j.bmc.2011.07.019

Cobb, A. (2011) General aspects of organocatalytic cyclizations. In: Mahrwald, R. (ed.) Enantioselective Organocatalyzed Reactions II: Asymmetric C-C Bond Formation Processes. Springer, pp. 1-40. ISBN 9789048138661

Fais, M., Karamanska, R., Allman, S., Fairhurst, S. A., Innocenti, P., Fairbanks, A. J., Donohoe, T. J., Davis, B. G., Russell, D. A. and Field, R. A. (2011) Surface plasmon resonance imaging of glycoarrays identifies novel and unnatural carbohydrate-based ligands for potential ricin sensor development. Chemical Science, 2 (10). pp. 1952-1959. ISSN 2041-6539 doi: 10.1039/c1sc00120e

Fante, C., Eldar-Boock, A., Satchi-Fainaro, R., Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457 and Greco, F. (2011) Synthesis and biological evaluation of a polyglutamic acid-dopamine conjugate: a new antiangiogenic agent. Journal of Medicinal Chemistry, 54 (14). pp. 5255-5259. ISSN 0022-2623 doi: 10.1021/jm200382r

Fern, S. E., Heath, P. and Cobb, A. J. A. (2011) Aldol reaction of butane-2,3-diacetal protected methyl glycerate. Tetrahedron: Asymmetry, 22 (2). pp. 149-152. ISSN 0957-4166 doi: 10.1016/j.tetasy.2011.01.004

Rassmussen, T. S., Allman, S., Twigg, G., Butters, T. D. and Jensen, H. H. (2011) Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease. Bioorganic & Medicinal Chemistry Letters, 21 (5). pp. 1519-1522. ISSN 0960-894X doi: 10.1016/j.bmcl.2010.12.106

Stachulski, A. V., Pidathala, C., Row, E. C., Sharma, R., Berry, N. G., Lawrenson, A. S., Moores, S. L., Iqbal, M., Bentley, J., Allman, S., Edwards, G., Helm, A., Hellier, J., Korba, B. E., Semple, J. E. and Rossignol, J.-F. (2011) Thiazolides as novel antiviral agents. 2. Inhibition of hepatitis C virus replication. Journal of Medicinal Chemistry, 54 (24). pp. 8670-8680. ISSN 0022-2623 doi: 10.1021/jm201264t

Stachulski, A.V., Pidathala, C., Row, E.C., Sharma, R., Berry, N.G., Iqbal, M., Bentley, J., Allman, S.A., Edwards, G., Helm, A., Hellier, J., Korba, B.E., Semple, J.E. and Rossignol, J.-F. (2011) Thiazolides as novel antiviral agents. 1. Inhibition of hepatitis B virus replication. Journal of Medicinal Chemistry, 54 (12). pp. 4119-4132. ISSN 0022-2623 doi: 10.1021/jm200153p

2010

Bauer, J., Stiller, J., Marques-Lopez, E., Strohfeldt, K. A., Christmann, M. and Strohmann, C. (2010) Silyl-Modified Analogues of 2-Tritylpyrrolidine: Synthesis and Applications in Asymmetric Organocatalysis. Chemistry - A European Journal, 16 (42). pp. 12553-12558. ISSN 0947-6539 doi: 10.1002/chem.201002166

Burland, P. A., Coisson, D. and Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457 (2010) Rapid synthesis of carbohydrate derivatives, including mimetics of c-linked disaccharides and c-Linked aza disaccharides, using the Hetero-Diels−Alder Reaction. Journal of Organic Chemistry, 75 (21). pp. 7210-7218. ISSN 0022-3263 doi: 10.1021/jo101219w

Carlescu, I., Osborn, H. M.I. ORCID: https://orcid.org/0000-0002-0683-0457, Desbrieres, J., Scutaru, D. and Popa, M. (2010) Synthesis of poly(aspartimide)-based bio-glycoconjugates. Carbohydrate Research, 345 (1). pp. 33-40. ISSN 0008-6215 doi: 10.1016/j.carres.2009.08.034

Kolstoe, S. E., Mangione, P. P., Bellotti, V., Taylor, G. W., Tennent, G. A., Deroo, S., Morrison, A. J., Cobb, A. J. A., Coyne, A., McCammon, M. G., Warner, T. D., Mitchell, J., Gill, R., Smith, M. D., Ley, S. V., Robinson, S. P. and Pepys, M. B. (2010) Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proceedings of the National Academy of Sciences of the United States of America, 107 (47). pp. 20483-20488. ISSN 0027-8424 doi: 10.1073/pnas.1008255107

Strohfeldt, K. and Grant, D. T. (2010) A model for self-directed problem-based learning for renal therapeutics. American Journal of Pharmaceutical Education, 74 (9). Article 173.

2009

Allman, S. A., Jensen, H. H., Vijayakrishnan, B., Garnett, J. A., Leon, E., Liu, Y., Anthony, D. C., Sibson, N. R., Feizi, T., Matthews, S. and Davis, B. G. (2009) Potent fluoro-oligosaccharide probes of adhesion in Toxoplasmosis. ChemBioChem, 10 (15). pp. 2522-2529. ISSN 1439-7633 doi: 10.1002/cbic.200900425

Garnett, J. A., Liu, Y., Leon, E., Allman, S. A., Friedrich, N., Saouros, S., Curry, S., Soldati-Favre, D., Davis, B. G., Feizi, T. and Matthews, S. (2009) Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) of Toxoplasma gondii. Protein Science, 18 (9). pp. 1935-1947. ISSN 0961-8368 doi: 10.1002/pro.204

Jawaid, S., Khan, T. H., Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457 and Williams, N. O. A. (2009) Tyrosinase activated melanoma prodrugs. Anti-cancer agents in medicinal chemistry, 9 (7). pp. 717-727. ISSN 1871-5206

Nodes, W., Nutt, D. R., Chippindale, A. M. ORCID: https://orcid.org/0000-0002-5918-8701 and Cobb, A. J. A. (2009) Enantioselective Intramolecular Michael Addition of Nitronates onto Conjugated Esters: Access to Cyclic γ-Amino Acids with up to Three Stereocenters. Journal of the American Chemical Society, 131 (44). pp. 16016-16017. ISSN 0002-7863 doi: 10.1021/ja9070915

Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457 and Turkson, A. (2009) Synthesis and NMR spectroscopic analysis of 3-nitro-pyranoside, 3-nitro-septanoside and 4-nitro-septanoside derivatives by condensation of the anion of nitromethane with glycoside. Tetrahedron Asymmetry, 20 (18). pp. 2162-2166. ISSN 0957-4166 doi: 10.1016/j.tetasy.2009.08.004

Vessieres, A., Plamont, M.-A., Cabestaing, C., Claffey, J., Dieckmann, S., Hogan, M., Mueller-Bunz, H., Strohfeldt, K. A. and Tacke, M. (2009) Proliferative and anti-proliferative effects of titanium- and iron-based metallocene anti-cancer drugs. Journal of Organometallic Chemistry, 694 (6). pp. 874-879. ISSN 0022-328X doi: 10.1016/j.jorganchem.2008.11.071

2008

Baksh, M. F. ORCID: https://orcid.org/0000-0003-3107-8815 and Kelly, P. (2008) Statistical methods for examining genetic influences of resistance to anti-epileptic drugs. Expert Review of Clinical Pharmacology, 1 (1). pp. 137-144. ISSN 1751-2433 doi: 10.1586/17512433.1.1.137

Bonjoch, J., Drew, M. G.B., Gonzalez, A., Greco, F., Jawaid, S., Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457, Williams, N. A.O. and Yaqoob, P. ORCID: https://orcid.org/0000-0002-6716-7599 (2008) Synthesis and evaluation of novel boron-containing complexes of potential use for the selective treatment of malignant melanoma. Journal of Medicinal Chemistry, 51 (20). pp. 6604-6608. ISSN 0022-2623 doi: 10.1021/jm8007745

Ellis, D., Norman, S. E. and Osborn, H. M. I. ORCID: https://orcid.org/0000-0002-0683-0457 (2008) Synthesis of S-linked carbohydrate analogues via a Ferrier reaction. Tetrahedron, 64 (12). pp. 2832-2854. ISSN 0040-4020 doi: 10.1016/j.tet.2008.01.042

Strohfeldt, K. A. and Tacke, M. (2008) Bioorganometallic fulvene-derived titanocene anti-cancer drugs. Chemical Society Reviews, 37 (6). pp. 1174-1187. ISSN 0306-0012 doi: 10.1039/b707310k

2007

Campo, V. L., Carvalho, I., Allman, S., Davis, B. G. and Field, R. A. (2007) Chemical and chemoenzymatic synthesis of glycosyl-amino acids and glycopeptides related to Trypanosoma cruzi mucins. Organic & Biomolecular Chemistry, 5 (16). pp. 2645-2657. ISSN 1477-0520 doi: 10.1039/b707772f

Gaynor, J. W., Brazier, J. ORCID: https://orcid.org/0000-0002-4952-584X and Cosstick, R. (2007) Synthesis of 3 '-S-phosphorothiolate oligonucleotides for their potential use in RNA interference. Nucleosides Nucleotides & Nucleic Acids, 26 (6-7). pp. 709-712. ISSN 1525-7770 doi: 10.1080/15257770701490753

2005

Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Shibata, T., Townsley, J., Taylor, B. F., Frary, E., Williams, N. H. and Williams, D. M. (2005) Amino-functionalized DNA: the properties of C5-amino-alkyl substituted 2′-deoxyuridines and their application in DNA triplex formation. Nucleic Acids Research, 33 (4). pp. 1362-1371. ISSN 1362-4962 doi: 10.1093/nar/gki254