Self-immolative systems for the disclosure of reactive electrophilic alkylating agents

Acton, A. L., Leroux, F., Feula, A., Melia, K., Sambrook, M. R., Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 and Russell, A. T. (2019) Self-immolative systems for the disclosure of reactive electrophilic alkylating agents. Chemical Communications, 55. pp. 5219-5222. ISSN 1359-7345 doi: 10.1039/C8CC09728C

Abstract/Summary

In this paper we report the design, synthesis and assessment of the first examples of self-immolative systems triggered by non-acidic electrophilic agents such as methyl, allyl or benzylic halides. These systems provide a visual colorimetric disclosure response upon exposure to these electrophilic reagents under mild, basic conditions without the need for the use of analytical instrumentation.