A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis

Coe, S., Cossington, J., Collett, J., Soundy, A., Izadi, H., Ovington, M., Durkin, L., Kirsten, M., Clegg, M., Cavey, A., Wade, D. T., Palace, J., DeLuca, G., Chapman, K., Harrison, J. M., Buckingham, E. and Dawes, H. (2019) A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 90. pp. 507-513. ISSN 0022-3050 doi: 10.1136/jnnp-2018-319496

Abstract/Summary

The impact of flavonoids on fatigue has not been investigated in Relapsing and Remitting Multiple Sclerosis (RRMS). Objective: To determine the feasibility and estimate the potential effect of flavonoid-rich cocoa on fatigue and fatigability in RRMS. Methods: A randomised double-blind placebo-controlled feasibility study in people recently diagnosed with RRMS and fatigue, throughout the Thames Valley (ISRCTN: 69897291). During a six week intervention participants consumed a high or low flavonoid cocoa beverage daily. Fatigue and fatigability were measured at three visits (weeks 0, 3 and 6). Feasibility and fidelity were assessed through recruitment and retention, adherence and a process evaluation. Results: 40 pwMS (10 men, 30 women, age 44 ± 10 yrs) were randomised and allocated to high (n=19) or low (n=21) flavonoid groups and included in analysis. Missing data was <20% and adherence to intervention of allocated individuals was >75%. There was a small effect on fatigue (Neuro-QoL: effect size {ES} 0.04; confidence interval {CI} -0.40-0.48) and a moderate effect on fatigability (six-minute walk test: ES 0.45; CI -0.18 - 1.07). There were seven adverse events (four control, three intervention), only one of which was possibly related and it was resolved. Conclusion: A flavonoid beverage demonstrates the potential to improve fatigue and fatigability in RRMS.

Item Type	Article
URI	https://reading-pure-test.eprints-hosting.org/id/eprint/81646
Identification Number/DOI	10.1136/jnnp-2018-319496
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
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