Ubiquitin sets the timer: impacts on aging and longevity

Kevei, E. ORCID: https://orcid.org/0000-0002-0560-9208 and Hoppe, T. (2014) Ubiquitin sets the timer: impacts on aging and longevity. Nature Structural and Molecular Biology, 21 (4). pp. 290-292. ISSN 1545-9993 doi: 10.1038/nsmb.2806

Abstract/Summary

Protein homeostasis is essential for cellular function, organismal growth and viability. Damaged and aggregated proteins are turned over by two major proteolytic routes of the cellular quality-control pathways: the ubiquitin-proteasome system and autophagy. For both these pathways, ubiquitination provides the recognition signal for substrate selection. This Commentary discusses how ubiquitin-dependent proteolytic pathways are coordinated with stress- and aging-induced signals.