Advances in ophthalmic drug delivery

Morrison, P. W. J. and Khutoryanskiy, V. V. ORCID: https://orcid.org/0000-0002-7221-2630 (2014) Advances in ophthalmic drug delivery. Therapeutic Delivery, 5 (12). pp. 1297-1315. ISSN 2041-5990 doi: 10.4155/tde.14.75

Abstract/Summary

Various strategies for ocular drug delivery are considered; from basic formulation techniques for improving availability of drugs; viscosity enhancers and mucoadhesives aid drug retention and penetration enhancers promote drug transport into the eye. The use of drug loaded contact lenses and ocular inserts allows drugs to be better placed where they are needed for more direct delivery. Developments in ocular implants gives a means to overcome the physical barriers that traditionally prevented effective treatment. Implant technologies are under development allowing long term drug delivery from a single procedure, these devices allow posterior chamber diseases to be effectively treated. Future developments could bring artificial corneas to eliminate the need for donor tissue and one-off implantable drug depots lasting the patient’s lifetime.