Association between dietary phyto-oestrogens and bone density in men and postmenopausal women

Kuhnle, G. G. C. ORCID: https://orcid.org/0000-0002-8081-8931, Ward, H. A., Vogiatzoglou, A., Luben, R. N., Mulligan, A., Wareham, N. J., Forouhi, N. G. and Khaw, K.-T. (2011) Association between dietary phyto-oestrogens and bone density in men and postmenopausal women. British Journal of Nutrition, 106 (7). pp. 1063-1069. ISSN 0007-1145 doi: 10.1017/S0007114511001309

Abstract/Summary

Phyto-oestrogens have been associated with a decreased risk for osteoporosis, but results from intervention and observational studies in Western countries have been inconsistent. In the present study, we investigated the association between habitual phyto-oestrogen intake and broadband ultrasound attenuation (BUA) of the calcanaeum as a marker of bone density. We collected 7 d records of diet, medical history and demographic and anthropometric data from participants (aged 45–75 years) in the European Prospective Investigation into Cancer-Norfolk study. Phyto-oestrogen (biochanin A, daidzein, formononetin; genistein, glycitein; matairesinol; secoisolariciresinol; enterolactone; equol) intake was determined using a newly developed food composition database. Bone density was assessed using BUA of the calcanaeum. Associations between bone density and phyto-oestrogen intake were investigated in 2580 postmenopausal women who were not on hormone replacement therapy and 4973 men. Median intake of total phyto-oestrogens was 876 (interquartile range 412) μg/d in postmenopausal women and 1212 (interquartile range 604) μg/d in men. The non-soya isoflavones formononetin and biochanin A were marginally significant or significantly associated with BUA in postmenopausal women (β = 1·2; P < 0·1) and men (β = 1·2; P < 0·05), respectively; enterolignans and equol were positively associated with bone density in postmenopausal women, but this association became non-significant when dietary Ca was added to the model. In the lowest quintile of Ca intake, soya isoflavones were positively associated with bone density in postmenopausal women (β = 1·4; P < 0·1). The present results therefore suggest that non-soya isoflavones are associated with bone density independent of Ca, whereas the association with soya or soya isoflavones is affected by dietary Ca.

Item Type	Article
URI	https://reading-pure-test.eprints-hosting.org/id/eprint/20335
Identification Number/DOI	10.1017/S0007114511001309
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences Central Services
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