Regulation of platelet biology by platelet endothelial cell adhesion molecule-1.

Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509, Moraes, L. A. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2012) Regulation of platelet biology by platelet endothelial cell adhesion molecule-1. Platelets, 23 (5). pp. 331-335. ISSN 0953-7104 doi: 10.3109/09537104.2011.626091

Abstract/Summary

Platelet endothelial cell adhesion molecule-1 (PECAM-1), an immunoreceptor tyrosine-based inhibitory motif containing receptor, plays diverse and apparently contradictory roles in regulating the response of platelets to stimuli; inhibiting platelet response to immunoreceptor tyrosine-based activation motif and G protein-coupled receptor signalling following stimulation with collagen, adenosine diphosphate, and thrombin, as well as enhancing integrin outside-in signalling. These dual, and opposing, roles suggest an important and complex role for PECAM-1 in orchestrating platelet response to vascular damage. Indeed, during thrombus formation, the influence of PECAM-1 on the multiple signalling pathways combines leading to a relatively large inhibitory effect on thrombus formation.