Statistical analysis plan for a cluster randomised controlled trial to compare screening, feedback and intervention for child anxiety problems to usual school practice: identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i).

Ball, S., Reardon, T., Creswell, C., Taylor, L., Brown, P., Ford, T., Gray, A., Hill, C., Jasper, B., Larkin, M., Macdonald, I., Morgan, F., Pollard, J., Sancho, M., Sniehotta, F. F., Spence, S. H., Stainer, J., Stallard, P., Violato, M. and Ukoumunne, O. C. (2024) Statistical analysis plan for a cluster randomised controlled trial to compare screening, feedback and intervention for child anxiety problems to usual school practice: identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i). Trials, 25. 62. ISSN 1745-6215 doi: 10.1186/s13063-023-07898-6

Abstract/Summary

Background: The Identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i) trial is being conducted to establish whether 'screening and intervention', consisting of usual school practice plus a pathway comprising screening, feedback and a brief parent-led online intervention (OSI: Online Support and Intervention for child anxiety), bring clinical and health economic benefits compared to usual school practice and assessment only - 'usual school practice', for children aged 8-9 years in the following: (1) the 'target population', who initially screen positive for anxiety problems according to a two-item parent-report child anxiety questionnaire - iCATS-2, and (2) the 'total population', comprising all children in participating classes. This article describes the detailed statistical analysis plan for the trial. Methods and design: iCATS-i2i is a definitive, superiority, pragmatic, school-based cluster randomised controlled trial (with internal pilot), with two parallel groups. Schools are randomised 1:1 to receive either screening and intervention or usual school practice. This article describes the following: trial objectives and outcomes; statistical analysis principles, including detailed estimand information necessary for aligning trial objectives, conduct, analyses and interpretation when there are different analysis populations and outcome measures to be considered; and planned main analyses, sensitivity and additional analyses. Trial registration: ClinicalTrials.gov ISRCTN76119074. Registered on 4 January 2022.

Item Type	Article
URI	https://reading-pure-test.eprints-hosting.org/id/eprint/114865
Identification Number/DOI	10.1186/s13063-023-07898-6
Refereed	Yes
Divisions	Life Sciences > School of Psychology and Clinical Language Sciences
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